Analyses treatment with INIs in combination with dual NRTI s

Analyses treatment with INIs in combination with dual NRTI showed to be more beneficial for treatment-naive patients compared to other currently used treatment strategies. Also in treatment-experienced patients with virological failure, use of INIs proved to be beneficial as well. However, in successfully treated patients with a history of therapy failure, switching a high genetic barrier drug towards an INI was not supported. In the EASIER-ANRS 138 trial two switch strategies were compared: one group switched MCE Company SCH-1473759 immediately to raltegravir, the second group continued the low genetic barrier drug enfuvirtide and switched only after 24 weeks. When analyzing the mITT 24 week data, the switch from enfuvirtide to raltegravir in heavily pretreated patients with a viral load,400 copies/ml at inclusion, resulted in similar rates of viral suppression. No raltegravir resistance was detected upon virological failure. Four smaller observational single-armed studies �C hence not include in the meta-analysis – evaluated the switch from enfuvirtide to raltegravir in patients with an undetectable viral load and reported high virological success rates at weeks 16 to 48. The ODIS trial evaluated two dosage schemes of raltegravir �C not included in the meta-analysis – while switching from a protease inhibitor and found that the 800 mg once daily arm had (R,S)-Ivosidenib higher rates of virological failure at 24 weeks compared to 400 mg twice-daily. In patients with prior NRTI resistance, significant higher failure rates were seen in both arms. RASTA compared switching to raltegravir 400 mg either with tenofovir/ emtricitabine or with abacavir/lamuvidine in patients on PI, NNRTI or NRTI-based therapy with suppressed viral load and found comparable virological suppression rates at 24 weeks. Only one patient experienced therapy failure after switch. Anecdotal data from another small study which could not be included in the meta-analysis, showed high virological suppression up to 48 weeks in 96 of patients following regimen simplification towards a low genetic barrier regimen with raltegravir plus nevirapine. Prior to the simplification, these patients were long term suppressed on a regimen containing nevirapine most likely without a history of therapy failure. Although several studies have been pe