All patients provided written informed consent for the collection of samples and subsequent analysis

Daily Living. AChE-Is: Cholinesterase Inhibitors. doi: bureaucratic and cumbersome task. Moreover, the potential proxy may be reluctant to make difficult decisions on behalf of the potential participant, and so may postpone the decision to take on this role. Finally, some families may perceive courts to be a stigmatizing place, thought primarily for criminal settings. As such they may be reluctant to attend court as part of the process of appointing a legal proxy. We can hypothesise that, due to the complexity and multiple implications of the procedure of appointment of the legal proxy, only some ��privileged��categories of patients succeed in achieving it. The results of our study partly support this view. We found indeed that the probability of appointing a legal proxy was associated with the younger patient’s age and the longer duration of the patient’s disease. This would suggest that the legal procedure is more often carried on by patients who have received an early diagnosis of dementia. Precocity of the diagnosis may be indicative of the patients’ and relatives’ stronger attention to the symptoms of dementia as well as their prompter access to the healthcare services. 18325633 Prompt access to the healthcare services may be 25581517 related to the patients’ and relatives’ more confident access to other public services, including the law courts. This is compatible with the slightly higher educational level of the patients who AVE-8062 started up the procedure of appointment of a legal proxy. Our data also suggest that the procedure of appointment was carried out by the patients who had a more stable and lasting relationship with our clinical centre. This view seems supported by the statistical association among the appointment of a legal proxy and the patient’s use of memantine and a quasi-significant association with the patient’s use of AChE-Is. Indeed, when the AdCare study was started, in the Lombardy region memantine was gratuitously distributed from clinical centres participating to a project coordinated by the Centre for Research and Treatment on Cognitive Dysfunctions, ��L. Sacco��Hospital. Since July June Dementia Research in Italy treatments. As compared to other patients, these patients accede to the Centre with: N N N more frequent scheduled visits; direct reservation with the centre availability of a mobile phone number to call at any time to notify adverse drug reactions. This ��preferential��treatment may have contributed to reinforce the trusting relationship among patients, their caregivers and the centre thus determining a more favourable attitude towards the suggestions of the centre’s staff, including the suggestion to provide legal agency to the patient. It is to note that the appointment of a legal proxy would have had no advantage nor any disadvantage for these patients as regarding the possibility to receive a beneficial treatment. As regarding reasons for not appointing a legal proxy, besides relatives’ reluctance to start up the procedure, we identified another obstacle, which is the time required to complete all the procedure once started. In fact, our data show that the median time required to carry out all the proceeding is on average twofold than that previewed by the law. Hence, the times required by the courts to appoint a legal representative may not be synchronised with the times required for an individual’s participation in research. For all these reasons the system which is actually in place in Italy seems far from effective in

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