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Categories. They rather correspond to properties of the (-)-Blebbistatin side effects fluxes in each category.PLOS ONE | DOI:10.1371/journal.pone.0120882 March 31,11 /A Generic Model of Dyadic Social RelationshipsTable 5. Detection of categories of action fluxes in data sets of dyadic interactions. Category 1 2 3 4 5 6 Pattern of observed fluxesX Alternated fluxes A! B and A XRepresentative relationship B A!B X A !B ;Y Y B, and separately, alternated fluxes A! B and A X ; XRMT EM NullNo fluxes between A and BX Alternated fluxes A! B and A X Alternated fluxes A! B and A X Fluxes A! B and A XB[A ! B and A ! B] Y X A!B YX [A! B and A X XXYMP ARYBB, not systematically alternatedB]CS AsocialFluxes A! BXA! BXPatterns of action fluxes expected to be observed in each category. X and Y are social actions belonging to a set S of size N. A and B are agents. doi:10.1371/journal.pone.0120882.t?Linked to the previous point, we stress that the patterns given in that table are not mutually disjoint. They should thus be tested in a certain order. MP should be tested before AR and CS, and category 6 (asocial) should be tested after all other categories. Let us illustrate that point with an example: if A and B are in an MP relationship, one observes alternated fluxes X X Y A ! B and A Y B, as well as alternated fluxes A ! B and A X B, re-written as [A ! B andY Y A ! B]. Yet, A and B’s relationship will also respond positive to a CS test, because non-alterX X nated fluxes A ! B and A X B are present overall in the relationship (indicative of CS for X), Y as well as non-alternated fluxes A ! B and A Y B (CS for Y). In that case, the alternation that marks an MP relationship should prevail in the observer’s interpretation because it is very unlikely to happen by chance alone.?A tolerance level should be defined for the alternation of fluxes (in EM, MP and AR). For instance, the alternation of fluxes in an EM relationship does not need to be strict. In real conditions, people can be flexible and take several turns in a row before the other party reciprocates. Occasional cheating or inexact record keeping can also occur within an otherwise stable relationship. Hence, a low tolerance could lead to false negatives, whereby the observer would miss situations of EM, MP and AR. On the other hand, high tolerance levels might lead to wrong interpretations: fluxes could be falsely interpreted as manifestations of EM, MP or AR. The adequate tolerance level may vary per data set or relationship and may be checked against the individuals’ communications, if available. ?Relationships may change over time. Individuals may initiate a certain relationship that transforms over time into another, linked to increased trust (or mistrust), availability of resources in the environment, and so on. To detect such changes, analyses can be carried out over different time windows. ?In any real data set, individuals may belong to larger social units that interact with each other. If blindly applied to all pairs of individuals, our model may miss these high-level effects. For instance, say that agent A from group G1 attacked B from group G2. Agent C from G2, feeling very close to B (perhaps in a CS way), decides to punish A and attacks her in an eye-for-an-eye, tooth-for-a-tooth fashion (EM). If one knows nothing of the groups exisX tence, one analyzes separately the pairs (A, B) and (A, C). From the EPZ-5676 site observations A ! B and A X C, one concludes to the presence of an asocial interaction (category 6) between A and B,PLO.Categories. They rather correspond to properties of the fluxes in each category.PLOS ONE | DOI:10.1371/journal.pone.0120882 March 31,11 /A Generic Model of Dyadic Social RelationshipsTable 5. Detection of categories of action fluxes in data sets of dyadic interactions. Category 1 2 3 4 5 6 Pattern of observed fluxesX Alternated fluxes A! B and A XRepresentative relationship B A!B X A !B ;Y Y B, and separately, alternated fluxes A! B and A X ; XRMT EM NullNo fluxes between A and BX Alternated fluxes A! B and A X Alternated fluxes A! B and A X Fluxes A! B and A XB[A ! B and A ! B] Y X A!B YX [A! B and A X XXYMP ARYBB, not systematically alternatedB]CS AsocialFluxes A! BXA! BXPatterns of action fluxes expected to be observed in each category. X and Y are social actions belonging to a set S of size N. A and B are agents. doi:10.1371/journal.pone.0120882.t?Linked to the previous point, we stress that the patterns given in that table are not mutually disjoint. They should thus be tested in a certain order. MP should be tested before AR and CS, and category 6 (asocial) should be tested after all other categories. Let us illustrate that point with an example: if A and B are in an MP relationship, one observes alternated fluxes X X Y A ! B and A Y B, as well as alternated fluxes A ! B and A X B, re-written as [A ! B andY Y A ! B]. Yet, A and B’s relationship will also respond positive to a CS test, because non-alterX X nated fluxes A ! B and A X B are present overall in the relationship (indicative of CS for X), Y as well as non-alternated fluxes A ! B and A Y B (CS for Y). In that case, the alternation that marks an MP relationship should prevail in the observer’s interpretation because it is very unlikely to happen by chance alone.?A tolerance level should be defined for the alternation of fluxes (in EM, MP and AR). For instance, the alternation of fluxes in an EM relationship does not need to be strict. In real conditions, people can be flexible and take several turns in a row before the other party reciprocates. Occasional cheating or inexact record keeping can also occur within an otherwise stable relationship. Hence, a low tolerance could lead to false negatives, whereby the observer would miss situations of EM, MP and AR. On the other hand, high tolerance levels might lead to wrong interpretations: fluxes could be falsely interpreted as manifestations of EM, MP or AR. The adequate tolerance level may vary per data set or relationship and may be checked against the individuals’ communications, if available. ?Relationships may change over time. Individuals may initiate a certain relationship that transforms over time into another, linked to increased trust (or mistrust), availability of resources in the environment, and so on. To detect such changes, analyses can be carried out over different time windows. ?In any real data set, individuals may belong to larger social units that interact with each other. If blindly applied to all pairs of individuals, our model may miss these high-level effects. For instance, say that agent A from group G1 attacked B from group G2. Agent C from G2, feeling very close to B (perhaps in a CS way), decides to punish A and attacks her in an eye-for-an-eye, tooth-for-a-tooth fashion (EM). If one knows nothing of the groups exisX tence, one analyzes separately the pairs (A, B) and (A, C). From the observations A ! B and A X C, one concludes to the presence of an asocial interaction (category 6) between A and B,PLO.

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