Ug-administered groups were compared, no significant differences were found in haemorrhage
Ug-administered groups were compared, no significant differences were found in haemorrhage and leucocyte infiltration scores (p > 0.05). Microscopic findings in the lung specimens revealed normal lung parenchyma in the group I (Figure 2A). In contrast, rats in the group II had disruption of normal alveolar structure with severe congestion and haemorrhage associated with Oxaliplatin molecular weight infiltrating leukocytes (Figure 2B). In the group IV and group V, the lungs of the contused rats exhibited moderate degrees of oedema and congestion (Figure 2C and 2D). Rats in the group VI and group III had significantly less leukocyte infiltration with relatively well- preserved alveolar histology compared to the group II (Figure 2E and 2F).Neutrophil count in BALContusion resulted in a significant increase in the neutrophil population (p = 0.003). Dxm decreased the neutrophil population significantly in the BAL PubMed ID: fluid of contused rats (p = 0.016) (Figure 1).Table 2 The activites of MDA, SOD and NO in serumGroups GroupI: Control (n = 7) GroupII: Sham(Cont) (n = 7) GroupIII: Cont + CoQ10 (n = 7) GroupIV: Cont + vit C (n = 7) GroupV: Cont + vit E (n = 7) GroupVI: Cont + Dxm (n = 7) MDA (mol/mg prot) 1.41 ?0.b aDiscussion PC is the most frequently diagnosed injury due to blunt thorax trauma. Because approximately 1/3 of trauma patients admitted to hospitals have thorax trauma, it is an important cause of mortality and morbidity. About 25 of the patients require invasive mechanical ventilation [2,4,5,7,16]. With the development of possible new pharmacological agents and better resuscitation methods, the need for mechanical ventilation may be decreased andSOD (U/mg prot) 4.38 ?0.52 1.14 ?0.b aNO (mol/L) 38.59 ?3.55b 82.61 ?8.01a 51.30 ?5.89ab 56.36 ?5.75ab 57.61 ?2. 30ab 50.98 ?8.53ab2.68 ?0.1.67 ?0.39b 1.71 ?0.b2.86 ?0.53ab 2.48 ?0.a1.89 ?0.40 1.77 ?0.b2.53 ?0.34ab 3.49 ?0.abDatas are presented as mean ?S.D. Cont: contusion, Dxm: Dexamethasone, vit C: vitamin C, vit E: vitamin E, CoQ10: Co enzyme Q10. a p < 0.05 in comparison with control. b p < 0.05 in comparison sham animals.Gokce et al. Journal of Cardiothoracic Surgery 2012, 7:92 5 ofFigure 1 Comparison of BAL fluid neutrophil counts per mm3 in each group. Contusion resulted in a significant increase in neutrophil population (p = 0.003). Contusion-induced neutrophil increase was reduced significantly by Dxm. administration compared to sham group (p = 0.016). *: p < 0.01 compared Group I, Mann whitney U test. : p < 0.05 compared Group II, Mann whitney U test. Group I: control. Group II: contusion (sham). Group III: contusion + CoQ10. Group IV: contusion + vitamin C. Group V: contusion + vitamin E. Group VI: contusion + dexamethasone.the prognosis of patients with PC may improve. For studying PC, various blunt thorax trauma models have been previously established. The local and systemic pathophysiological consequences of PC and the different treatment strategies to minimize the effects of this type of injury have been studied [8,10-13,26-29]. In our study, we used the rat model of lung contusion injury caused by external blunt thoracic trauma as described by Raghavendran et al. [14]. We generated and adapted the rat model mentioned above in order to constitute a moderate PC. The effects of the PC depend on the extent of the injury. Direct injury causes pulmonary vascular damage with secondary alveolar haemorrhage, and thus the alveoli are poorly perfused. Afterwards,.

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