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Ed the conceptual design of the study, the preparation of the
Ed the conceptual design of the study, the preparation of the manuscript, and the interpretation of the results. FB and AW provided scripts for random pruning and edited the manuscript, OAA edited the manuscript. All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Consent of publication Not applicable Ethics approval and consent to participate No patient samples were collected and analysed FPS-ZM1 mechanism of action during this study. All GWAS data were provided as summary statistics by the consortia acknowledged in this study having been collected in accordance with ethical regulations in the partner countries and as defined in original research publications by such consortia.Publisher’s NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Author details 1 Prostate Cancer Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo, Norway. 2NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 3Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. 4European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. 5Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK. 6Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. 7PCUK Movember Centre of Excellence, CCRCB, Queen’s University, Belfast, UK. Received: 3 March 2016 Accepted: 11 MarchReferences 1. Welter D, MacArthur J, Morales J, Burdett T, Hall P, Junkins H, Klemm A, Flicek P, Manolio T, Hindorff L, et al. The NHGRI GWAS Catalog, a curatedZuber et al. BMC Genomics (2017) 18:Page 11 of2.3.4.5. 6. 7.8.9. 10.11.12.13.14.15.16.17.18.19.20.21.resource of SNP-trait associations. Nucleic acids research. 2014;42(Database issue):D1001?006. Tehranchi AK, Myrthil M, Martin T, Hie BL, Golan D, Fraser HB. Pooled ChIPSeq Links Variation in Transcription Factor Binding to Complex Disease Risk. Cell. 2016;165(3):730?1. Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, Reynolds AP, Sandstrom R, Qu H, Brody J, et al. Systematic localization of common disease-associated variation in regulatory DNA. Science (New York, NY). 2012;337(6099):1190?. Coetzee SG, Shen HC, Hazelett DJ, Lawrenson K, Kuchenbaecker K, Tyrer J, Rhie SK, Levanon K, Karst PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28151467 A, Drapkin R et al.: Cell Type Specific Enrichment Of Risk Associated Regulatory Elements At Ovarian Cancer Susceptibility Loci. Human molecular genetics. 2015;24(13):3595?07. Paul DS, Soranzo N, Beck S. Functional interpretation of non-coding sequence variation: concepts and challenges. Bioessays. 2014;36(2):191?. Ritchie GR, Dunham I, Zeggini E, Flicek P. Functional annotation of noncoding sequence variants. Nat Methods. 2014;11(3):294?. Huang CN, Huang SP, Pao JB, Chang TY, Lan YH, Lu TL, Lee HZ, Juang SH, Wu PP, Pu YS, et al. Genetic polymorphisms in androgen receptor-binding sites predict survival in prostate cancer patients receiving androgendeprivation therapy. Ann Oncol. 2012;23(3):707?3. Hazelett DJ, Rhie SK, Gaddis M, Yan C, Lakeland DL, Coetzee SG, Henderson BE, Noushmehr H, Cozen W, Kote-Jarai Z, et al. Comprehensive functional annotation of 77 prostate cancer risk loci. PLoS genetics. 2014;10(1): e1004102. Corradin O, Scache.

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