Product Name :
Madrasin
Description:
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.
CAS:
374913-63-0
Molecular Weight:
311.34
Formula:
C16H17N5O2
Chemical Name:
2-((7-Methoxy-4-methylquinazolin-2-yl)amino)-5,6-dimethylpyrimidin-4(3H)-one
Smiles :
COC1=CC2=NC(NC3NC(=O)C(C)=C(C)N=3)=NC(C)=C2C=C1
InChiKey:
QQJIYKXTEMDJFM-UHFFFAOYSA-N
InChi :
InChI=1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Giemsa stain} MedChemExpress|{Giemsa stain} {Fluorescent Dye}|{Giemsa stain} Biological Activity|{Giemsa stain} In stock|{Giemsa stain} custom synthesis|{Giemsa stain} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.|Product information|CAS Number: 374913-63-0|Molecular Weight: 311.34|Formula: C16H17N5O2|Synonym:|DDD00107587|RNA splicing inhibitor|Madrasin|Chemical Name: 2-((7-Methoxy-4-methylquinazolin-2-yl)amino)-5,6-dimethylpyrimidin-4(3H)-one|Smiles: COC1=CC2=NC(NC3NC(=O)C(C)=C(C)N=3)=NC(C)=C2C=C1|InChiKey: QQJIYKXTEMDJFM-UHFFFAOYSA-N|InChi: InChI=1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Cynarin} site|{Cynarin} Anti-infection|{Cynarin} Protocol|{Cynarin} Purity|{Cynarin} supplier|{Cynarin} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:24458656 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Madrasin (10-30 μM; 4-24 hours; HeLa cells) treatment inhibits the splicing of each of the RIOK3, BRD2, and Hsp40, MCL1, CCNA2, AURKA and p27 pre-mRNAs in both HeLa and HEK293 cells. Madrasin (10-30 μM; 4-24 hours; HeLa and HEK293 cells) treatment shows a dose- and time-dependent inhibitory effect on cell cycle progression.|References:|Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.Products are for research use only. Not for human use.|
