Product Name :
AG14361
Description:
AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells.
CAS:
328543-09-5
Molecular Weight:
320.39
Formula:
C19H20N4O
Chemical Name:
1-(4-((dimethylamino)methyl)phenyl)-8, 9-dihydro-2, 7, 9a-triazabenzo[cd]azulen-6(7H)-one.
Smiles :
CN(C)CC1C=CC(=CC=1)C1=NC2=CC=CC3C(=O)NCCN1C=32
InChiKey:
SEKJSSBJKFLZIT-UHFFFAOYSA-N
InChi :
InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Sacituzumab govitecan} site|{Sacituzumab govitecan} Immunology/Inflammation|{Sacituzumab govitecan} Purity & Documentation|{Sacituzumab govitecan} In stock|{Sacituzumab govitecan} custom synthesis|{Sacituzumab govitecan} Autophagy}
Additional information:
AG14361 is a PARP-1 inhibitor with Ki Product information|CAS Number: 328543-09-5|Molecular Weight: 320.39|Formula: C19H20N4O|Synonym:|AG-14361|Chemical Name: 1-(4-((dimethylamino)methyl)phenyl)-8, 9-dihydro-2, 7, 9a-triazabenzo[cd]azulen-6(7H)-one.|Smiles: CN(C)CC1C=CC(=CC=1)C1=NC2=CC=CC3C(=O)NCCN1C=32|InChiKey: SEKJSSBJKFLZIT-UHFFFAOYSA-N|InChi: InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fluvoxamine} site|{Fluvoxamine} Serotonin Transporter|{Fluvoxamine} Purity & Documentation|{Fluvoxamine} Formula|{Fluvoxamine} manufacturer|{Fluvoxamine} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:23710097 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AG14361 is a potent PARP-1 inhibitor, with a Ki of In Vivo:|AG14361 (5 and 15 mg/kg, i.p.) has no toxicity and does not inhibit the growth of tumor. However, AG14361 markedly enhances NSC 362856 activity against LoVo xenografts and delays tumor growth when combined with NSC 362856. AG14361 (15 mg/kg, i.p.) treatment before irradiation dramaticly increases the sensitivity to radiation therapy of mice bearing LoVo xenografts[1]. AG14361 (30 mg/kg) synergizes lestaurtinib activity on inhibiting breast cancer tumors in allografts|Products are for research use only. Not for human use.|
