Product Name :
F16
Description:
F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell.
CAS:
36098-33-6
Molecular Weight:
362.21
Formula:
C16H15IN2
Chemical Name:
4-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methylpyridin-1-ium iodide
Smiles :
[I-].C[N+]1C=CC(/C=C/C2=CNC3=CC=CC=C23)=CC=1
InChiKey:
UURAKYSOOXPORG-UHFFFAOYSA-N
InChi :
InChI=1S/C16H14N2.HI/c1-18-10-8-13(9-11-18)6-7-14-12-17-16-5-3-2-4-15(14)16;/h2-12H,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.L-Cystine supplier
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Omalizumab Purity
Additional information:
F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines.PMID:32434821 F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell.|Product information|CAS Number: 36098-33-6|Molecular Weight: 362.21|Formula: C16H15IN2|Chemical Name: 4-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methylpyridin-1-ium iodide|Smiles: [I-].C[N+]1C=CC(/C=C/C2=CNC3=CC=CC=C23)=CC=1|InChiKey: UURAKYSOOXPORG-UHFFFAOYSA-N|InChi: InChI=1S/C16H14N2.HI/c1-18-10-8-13(9-11-18)6-7-14-12-17-16-5-3-2-4-15(14)16;/h2-12H,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 31 mg/mL (85.59 mM) Ethanol : 1 mg/mL (2.76 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines. F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells.|References:|Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42.Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36.Products are for research use only. Not for human use.|
