Product Name: DNA polymerase iota antibody [N3C2], Internal
Applications: WB
Predicted Target Size: 83 kDa (note)
Positive Controls: PC-3 , SK-N-SH
Form Supplied: Liquid
Concentration: 0.85 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: polymerase (DNA directed) iota
Background: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Synonyms: RAD30B antibody, RAD3OB antibody, POLI antibody, “polymerase (DNA-directed), iota antibody”, RAD30 homolog B antibody, eta2 antibody, DNA polymerase iota antibody, polymerase (DNA directed) iota antibody
Cellular Localization: Nucleus
CAS NO: 223104-29-8
Product: Atrasentan (hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human DNA polymerase iota. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23510717?dopt=Abstract
