Product Name: DORFIN antibody
Applications:
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: IgG fraction
Full Name: ring finger protein 19A
Background: The protein contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinsons disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
Synonyms: 607119, RNF19, DKFZp566B1346, DORFIN, Q9NV58, 25897
Cellular Localization:
CAS NO: 864070-44-0
Product: LY2835219 (free base)
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: Peptide with sequence QTMELKVAIQTEI, from C Terminus of the protein sequence according to NP_056250.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Storage Instruction: Upon receipt – Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19056354?dopt=Abstract
