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Product Name: Drebrin antibody [M2F6]
Applications: IHC-Fr, IHC-P, WB
Predicted Target Size:
Positive Controls: Mouse Brain Tissue Extract
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A purified
Full Name: drebrin 1
Background: The cortical cytoskeleton, a highly cross-linked submembranal F-actin filament network, plays an important role in cell proliferation, differentiation, migration, cell morphology and oncogenic transformation. Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa). An additional truncated form of drebrin A, s-drebrin/A2 (42 kDa), is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.
Synonyms: 1627, DKFZp434D064, Q16643, DBN1, 126660, D0S117E, Drebrin
Cellular Localization: Cytoplasmic
CAS NO: 2854-32-2
Product: LDE225 (Diphosphate)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Immunogen: Chicken Drebrin E protein.
Antigen Species: Chicken
Species Reactivity: Human, Mouse, Pig, Rat, Cat, Guinea pig
Conjugation: Unconjugated
Storage Buffer: Preservative: NoneConstituents: PBS, 10mg/ml Sucrose. pH 7.2
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody detects Drebrin A and E in samples from human, mouse, rat, guinea pig, and cat origins and Drebrin E only in chicken samples.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/15277541?dopt=Abstract

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