Product Name: DUSP14 antibody [C2C3], C-term
Applications: WB
Predicted Target Size: 22 kDa (note)
Positive Controls: MKP-6 tansfected 293T cell
Form Supplied: Liquid
Concentration: 2 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity purified by Protein A.
Full Name: dual specificity phosphatase 14
Background: In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM]
Synonyms: MKP-L antibody, MKP6 antibody, DUSP14 antibody, dual specificity protein phosphatase 14 antibody, MAP kinase phosphatase 6 antibody, MKP-6 antibody, MKP-1-like protein tyrosine phosphatase antibody, MKP-1 like protein tyrosine phosphatase antibody, mitogen-activated protein kinase phosphatase 6 antibody, dual specificity phosphatase 14 antibody
Cellular Localization:
CAS NO: 223132-37-4
Product: Ampalex
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DUSP14. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27475251?dopt=Abstract
