Product Name: DUSP8 antibody
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: IgG fraction
Full Name: dual specificity phosphatase 8
Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq]
Synonyms: 1850, Q13202, HVH-5, HVH5, HVH8, DUSP8, HB5, 602038, C11orf81, FLJ42476, FLJ42958, HVH 5
Cellular Localization:
CAS NO: 165800-03-3
Product: SB-408124 (Hydrochloride)
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: Peptide with sequence AGDRLPRKVMDAK, from N-Terminal of the protein sequence according to NP_004411
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Storage Instruction: Upon receipt – Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is also expected to recognise the hypothetical human protein similar to dual specificity phosphatase 8 (XM_114902), which is virtually identical.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27578798?dopt=Abstract
