Product Name: DUT-N antibody
Applications: WB
Predicted Target Size:
Positive Controls: HeLa cell lysate.
Form Supplied:
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G purified
Full Name: deoxyuridine triphosphatase
Background: Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a ubiquitous enzyme that functions in the hydrolysis of dUTP to dUMP and pyrophosphate. Canman and co-workers have demonstrated that, in certain human tumor cell lines, increased levels of dUTPase are responsible for an increase in resistance to the cancer chemotherapeutic agent fluorodeoxyuridine (FUdR), a thymidine synthase inhibitor. Two distinct forms of dUTPase exist in humans. Cellular fractionation experiments suggest that the more abundant, lower mass form of dUTPase (DUT-N) localizes in the nucleus, while the higher mass form (DUT-M) is associated with the mitochondria.
Synonyms: 601266, dUTPase, DUT, DUTN, 1854, P33316
Cellular Localization: Nuclear
CAS NO: 1096708-71-2
Product: Idarubicin (hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide, corresponding to amino acids 25-44 (NARGTAEGRSRGTLRARPAP) and 113-130 (QLRFARLSEHATAPTRGS) of Human DUT-N.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.02% Sodium Azide; Constituents: PBS
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27630194?dopt=Abstract
