Product Name: Dynamin 1 antibody [4E67]
Applications: IHC, IP, WB
Predicted Target Size:
Positive Controls: Mouse Brain Tissue Extract
Form Supplied:
Concentration: 0.55 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G purified
Full Name: dynamin 1
Background: Dynamin is a 100 kDa GTP binding protein that was first identified as a protein able to bind microtubules. A mutation in the Drosophila gene shits, encoding a dynamin homologue, prevents synaptic vesicle recycling and causes temperature-sensitive paralysis, implicating dynamin in the formation of coated vesicles. Dynamin may mediate vesicle formation by assembling into a ring structure around the necks of invaginated coated pits that may eventually lead to the closure of the neck and formation of vesicles. Amphiphysin, dynamin, clathrin and AP2 form a complex during synaptic vesicle endocytosis, which is regulated by the phosphorylated state of different components in this complex. To date, three genes have been found to encode dynamin isoforms. Dynamin 1 is neuronal specific, Dynamin 2 is ubiquitously expressed and Dynamin 3 localizes to testis, brain and lung.
Synonyms: 1759, Dynamin 1, 602377, Q05193, DNM1, DNM, Dynamin1
Cellular Localization: Microtubule associated.
CAS NO: 1032568-63-0
Product: 10-Deacetylbaccatin III
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Immunogen: Recombinant fragment, (His)6 tagged, corresponding to amino acids 1-750 of Human Dynamin 1.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat, Bovine
Conjugation: Unconjugated
Storage Buffer: Preservative: None; Constituents: 0.1mM PMSF, PBS, 40% glycerol.
Storage Instruction: May be stored at 4°C for short-term only. For long-term storage, store at -20°C.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27848911?dopt=Abstract
