Product Name: Dynamin antibody [0.T.178]
Applications: ICC/IF, IP, WB
Predicted Target Size:
Positive Controls: Bovine brain cytosol
Form Supplied:
Concentration: Batch dependent (Please refer to the vial label for the specific concentration)
Purification: Protein G purified
Full Name: dynamin 1
Background: Dynamin is a GTPase required for endocytosis of clathrin coated vesicles from the membrane. Dynamins involvement in endocytosis was first discovered during the characterization of the temperature sensitive parylytic shibire mutation from Drosophila melanogaster. Three closely related isoforms have been identified in mammals. Dynamin1 is expressed exclusively in neurons, dynamin2 is ubiquitously expressed and dynamin3 is expressed primarily in the testes. Each of these isoforms of dynamin also has several splice variants. This suggests that each isoform/splice variant may have separate intracellular targets or function in the budding of distinct vesicle types. Common domain features of the dynamin proteins include an amino acid terminal GTPase domain, a central pleckstrin homology domain and a highly basic proline rich carboxyl terminus with several Src homology 3 (SH3) domains. These SH3 domains target the dynamin to the clathrin coated pit. Dynamin is known to interact with at least two proteins, AP2 adaptor protein complex and amphiphysin.
Synonyms: 1759, 602377, Q05193, DNM1, Dynamin, DNM
Cellular Localization: Microtubule associated.
CAS NO: 1041434-82-5
Product: Trelagliptin (succinate)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Immunogen: Recombinant full length protein (Human).
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat, Bovine
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.05% Sodium Azide; Constituents: PBS, 40 % glycerol
Storage Instruction: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26537451?dopt=Abstract
