Product Name: DYRK1A antibody, N-term
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: Batch dependent mg/ml (Please refer to the vial label for the specific concentration)
Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Background: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq]
Synonyms: HP86, Protein kinase minibrain homolog, Dual specificity YAK1related kinase, DYRK1A, Dual specificity YAK1-related kinase, MNBH, hMNB
Cellular Localization:
CAS NO: 1262843-46-8
Product: Zardaverine
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.
Antigen Species: Human
Species Reactivity:
Conjugation: Unconjugated
Storage Buffer: PBS, 0.09% sodium azide.
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26714106?dopt=Abstract
