Product Name: E2F1 antibody [N2C2], Internal
Applications: ICC/IF, WB
Predicted Target Size: 47 kDa (note)
Positive Controls: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , NIH-3T3
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: E2F transcription factor 1
Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq]
Synonyms: E2F-1 antibody, RBAP1 antibody, RBBP3 antibody, RBP3 antibody, E2F1 antibody, retinoblastoma-binding protein 3 antibody, RBAP-1 antibody, PRB-binding protein E2F-1 antibody, RBBP-3 antibody, transcription factor E2F1 antibody, PBR3 antibody, retinoblastoma-associated protein 1 antibody, E2F transcription factor 1 antibody
Cellular Localization: Nucleus
CAS NO: 122852-43-1
Product: BMN-673
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human E2F1. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25393912?dopt=Abstract
