Product Name: E-Cadherin (phospho Ser838/840) antibody
Applications: IP, WB
Predicted Target Size: 97 kDa (note) (4)
Positive Controls: MCF-7 , MCF-7 CIP , PI , Rat brain
Form Supplied: Liquid
Concentration: 0.3 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: cadherin 1, type 1, E-cadherin (epithelial)
Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq]
Synonyms: E-Cadherin phospho Ser838, Ser840 Antibody , ECAD Antibody , phospho Ser838, Ser840 E-Cadherin Antibody , CDHE Antibody , CDH1 Antibody , E-Cadherin phospho S838, S840 Antibody , E-Cadherin (pS838, pS840) Antibody , E-Cadherin (pSer838, pSer840) Antibody , phospho E-Cadherin (S838, S840) Antibody , E-Cadherin phospho Antibody , E-Cadherin (phospho Ser838, phospho Ser840) Antibody , Arc-1 Antibody , phospho E-Cadherin (pSer838, pSer840) Antibody , UVO Antibody , CD324 Antibody , phospho S838, S840 E-Cadherin Antibody , phospho E-Cadherin Antibody , phospho E-Cadherin (pS838, pS840) Antibody , LCAM Antibody , E-Cadherin (phospho S838, phospho S840) Antibody , cadherin 1, type 1, E-cadherin (epithelial) Antibody
Cellular Localization: Cell junction , Cell membrane
CAS NO: 154447-36-6
Product: GW3965 (hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human E-Cadherin. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Rat
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24400120?dopt=Abstract
