Product Name: E-Cadherin antibody [7H12]
Applications: ELISA, FACS, IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Unpurified
Full Name: cadherin 1
Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Synonyms: ECAD Antibody , CDHE Antibody , CD324 Antibody , UVO Antibody , LCAM Antibody , ARC1 Antibody , CDH1 Antibody
Cellular Localization:
CAS NO: 648450-29-7
Product: VTP-27999 (Hydrochloride)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Purified recombinant fragment of human CDH1 expressed in E. Coli.
Antigen Species: Human
Species Reactivity: Human, Mouse, Monkey
Conjugation: Unconjugated
Storage Buffer: Ascites, 0.03% sodium azide
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24282276?dopt=Abstract
