Product Name: E-Cadherin antibody [GT358]
Applications: ICC/IF, WB
Predicted Target Size: 97 kDa (note) (2)
Positive Controls: MCF-7
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity purified by Protein G.
Full Name: cadherin 1, type 1, E-cadherin (epithelial)
Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq]
Synonyms:
Cellular Localization: Cell junction, Cell membrane
CAS NO: 915019-65-7
Product: Lapatinib (ditosylate)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b
Immunogen: Recombinant protein encompassing a sequence within the center region of human E-Cadherin. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24618750?dopt=Abstract
