Product Name: E-Cadherin antibody [RM244]
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A affinity purified from an animal origin-free culture supernatant
Full Name: cadherin 1
Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Synonyms: Arc1 Antibody , CDHE Antibody , CD324 Antibody , CDH1 Antibody , ECAD Antibody , UVO Antibody , LCAM Antibody , cadherin 1 Antibody
Cellular Localization:
CAS NO: 153559-49-0
Product: I2906
Host: Rabbit
Clonality: Monoclonal
Isotype: Rabbit IgG
Immunogen: A peptide corresponding to Cadherin-1
Antigen Species:
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage Instruction: Store at -20.0°C
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody reacts to human E-cadherin (Cadherin-1).
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24647936?dopt=Abstract
