Product Name: ECSIT antibody
Applications: ELISA, IHC-P, WB
Predicted Target Size:
Positive Controls: Blocking Peptide:Cat. No. GTX85081-PEP – ECSIT PeptideLysates:Cat. No. GTX27916 – Human Heart Tissue LysateCat. No. GTX27932 – Mouse Heart Tissue Lysate
Form Supplied: Liquid
Concentration:
Purification: Ion exchange chromatography purified
Full Name: ECSIT homolog (Drosophila)
Background: Activation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.
Synonyms: ECSIT
Cellular Localization:
CAS NO: 918633-87-1
Product: TG 100801
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: Human ECSIT (C-Terminus) Peptide
Antigen Species:
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Antibody is supplied in PBS containing 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for ECSIT
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24788257?dopt=Abstract
