Product Name: EDG3 antibody [AS61]
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A affinity purified.
Full Name: sphingosine-1-phosphate receptor 3
Background: EDG3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several protein tyrosine kinases. EDG3 is expressed in heart, placenta, kidney, and liver tissue.
Synonyms: 601965, FLJ37523, 1903, EDG-3, S1PR3, Q99500, MGC71696, S1P3, LPB3, EDG3, EDG 3
Cellular Localization: Nuclear
CAS NO: 1138549-36-6
Product: Methylnaltrexone (Bromide)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Immunogen: Synthetic peptide to C-terminal region of EDG3 (Human).
Antigen Species: Human
Species Reactivity: Human, Rat
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.08% sodium azide; Constituents: PBS
Storage Instruction: Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The antibody does not recognize EDG2, 4 or 5.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24743596?dopt=Abstract
