Product Name: EGFR (phospho Ser1046) antibody
Applications: IHC-P, WB
Predicted Target Size: 175 (note)
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Full Name: epidermal growth factor receptor
Background: Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
Synonyms: ERBB, ERBB1, HER1, PIG61, mENA, EGFR, receptor tyrosine-protein kinase erbB-1, cell growth inhibiting protein 40, epidermal growth factor receptor, proto-oncogene c-ErbB-1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell proliferation-inducing protein 61
Cellular Localization:
CAS NO: 928774-43-0
Product: PF-03814735
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: Peptide sequence around phosphorylation site of serine 1046 (R-Y-S(p)-S-D) derived from Human EGFR.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The full-length EGFR includes the 24 aa signal peptide that is cleaved during EGFR maturation. The Ser1046 of mature EGFR is equivalent to Ser1070 of uncleaved EGFR.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24046080?dopt=Abstract
