Product Name: EGFR antibody [E114], C-term
Applications: ICC/IF, IHC, IHC-P, IP, WB
Predicted Target Size: 170-180 (note)
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Tissue culture supernatant
Full Name: epidermal growth factor receptor
Background: Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation . Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor . Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal of EGFR . Autophosphorylation of Tyr 992 creates a binding site for the phospholipase C-gamma (PLC-gamma) SH2 domain, inducing downstream signaling .
Synonyms: ERBB1, HER1, EGFR, ERBB, mENA, PIG61
Cellular Localization:
CAS NO: 107233-08-9
Product: MK-2894
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Immunogen: A synthetic peptide corresponding to residues near C-terminus of human EGF receptor was used as immunogen.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Instruction: Store at -20 °C. Stable for 12 months from date of receipt.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,488.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23708604?dopt=Abstract
