Product Name: ENC1 antibody [C1C3]
Applications: WB-Ag
Predicted Target Size: 66 kDa (note)
Positive Controls: Target recombinant protein
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: ectodermal-neural cortex 1 (with BTB-like domain)
Background: DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes p53-induced genes, or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM]
Synonyms: CCL28 antibody, ENC-1 antibody, FLJ39259 antibody, KLHL35 antibody, KLHL37 antibody, NRPB antibody, PIG10 antibody, TP53I10 antibody, ENC1 antibody, “nuclear restricted protein, BTB domain-like (brain) antibody”, nuclear matrix protein NRP/B antibody, kelch-like protein 37 antibody, kelch-like 37 antibody, ectoderm-neural cortex protein 1 antibody, ectodermal-neural cortex (with BTB-like domain) antibody, p53-induced gene 10 protein antibody, tumor protein p53 inducible protein 10 antibody, kelch-like 35 antibody, ectodermal-neural cortex 1 (with BTB-like domain) antibody
Cellular Localization:
CAS NO: 19171-19-8
Product: CGS 21680
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human ENC1. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity:
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21245191?dopt=Abstract
