Product Name: EP300 antibody [RW128]
Applications: ICC/IF, IP, WB
Predicted Target Size:
Positive Controls: HeLa nuclear extracts
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification:
Full Name: E1A binding protein p300
Background: p300 is a relatively stable, ubiquitously expressed, nuclear phosphoprotein which is conserved among a variety of mammalian species. It is actively synthesized and phosphorylated in both quiescent and proliferating cells. Cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP) and p300 are closely related transcriptional coactivators and have been shown to directly interact with many different DNA-binding transcription factors including nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Both CBP and p300 have been shown to display histone acetyltransferase (HAT) activity, capable of acetylating all four core histone particles in nucleosomes. As a result of HAT activity, it has been suggested CBP and p300 may play a direct role in activating chromatin for transcription.
Synonyms: KAT3B, RSTS2, p300
Cellular Localization: Nuclear
CAS NO: 273404-37-8
Product: Vinorelbine
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Fusion protein containing residues 1572-2371 of human p300.
Antigen Species: Human
Species Reactivity: Human, Mouse, Monkey, Rat, Mink
Conjugation: Unconjugated
Storage Buffer: PBS [pH7.4] containing 0.1% sodium azide
Storage Instruction: Aliquot and store in working volumes at -20 degrees Celcius or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for p300 protein. This antibody recognizes residues 1868-1921.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24748367?dopt=Abstract
