Product Name: ITCH (phospho Tyr420) antibody
Applications: IHC-P
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Full Name: itchy E3 ubiquitin protein ligase
Background: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Synonyms: NAPP1 Antibody , itchy E3 ubiquitin protein ligase Antibody , ITCH Antibody , AIF4 Antibody , AIP4 Antibody , dJ468O1.1 Antibody
Cellular Localization:
CAS NO: 883986-34-3
Product: 6α-Methylprednisolone 21-hemisuccinate (sodium salt)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Peptide sequence around phosphorylation site of tyrosine 420(F-I-Y(p)-G-N) derived from Human ITCH .
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Store at -20˚C/1 year
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The antibody detects endogenous levels of ITCH only when phosphorylated at tyrosine 420.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22528479?dopt=Abstract
