Product Name: ITCH antibody
Applications: ELISA, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity Chromatography Purified Via Peptide Column.
Full Name: itchy E3 ubiquitin protein ligase
Background: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Synonyms: AIF4 Antibody , dJ468O1.1 Antibody , AIP4 Antibody , NAPP1 Antibody , itchy E3 ubiquitin protein ligase Antibody
Cellular Localization:
CAS NO: 947914-18-3
Product: Ftaxilide
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: ITCH antibody was raised against a 15 amino acid peptide near the amino terminus of human ITCH
Antigen Species: Human
Species Reactivity: Mouse
Conjugation: Unconjugated
Storage Buffer: PBS containing 0.02% sodium azide.
Storage Instruction: Stored At 4ºc For Three Months And -20ºc, Stable For Up To One Year.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: ITCH antibody is human, mouse and rat reactive. At least three isoforms of ITCH are known to exist; this antibody only recognizes the two longest isoforms. This antibody is predicted to not cross-react with other members of the Nedd4 protein family.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22549466?dopt=Abstract
