Product Name: ITK antibody [2F12]
Applications: IP, WB
Predicted Target Size:
Positive Controls: Jurkat cells
Form Supplied: Liquid
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G purified
Full Name: IL2-inducible T-cell kinase
Background: ITK is a T cell signaling protein. The Tec family of non receptor tyrosine kinases is composed of six proteins designated Tec, ITK (also known as Emt or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini. Tik associates with CD28 and becomes activated subsequent to CD28 ligation.
Synonyms: Emt, Tcsk, Tsk
Cellular Localization: Plasma membrane
CAS NO: 290297-26-6
Product: Modaline (sulfate)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Recombinant full length protein (Mouse).
Antigen Species: Mouse
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21673110?dopt=Abstract
