Product Name: JAK1 (phospho Tyr1022/1023) antibody
Applications: WB
Predicted Target Size:
Positive Controls: 3T3 L1 adipocytes +/- Leukemia Inhibitory Factor (LIF)
Form Supplied: Liquid
Concentration:
Purification: Immunogen affinity purified
Full Name: Janus kinase 1
Background: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and
Synonyms: phospho Y1022/1023 JAK1 Antibody , JAK1 (Phospho Tyr1022/1023) Antibody , JAK1B Antibody , JAK1 Y1022/1023 phospho Antibody , phospho JAK1 Y1022/1023 Antibody , JAK1 phospho Antibody , JAK1 phospho Tyr1022/1023 Antibody , JAK1A Antibody , Phospho JAK1 (pY1022/1023) Antibody , JTK3 Antibody , JAK1 (Phospho Y1022/1023) Antibody , JAK1 phospho Y1022/1023 Antibody , JAK1 (pTyr1022/1023) Antibody , phospho Tyr1022/1023 JAK1 Antibody , JAK1 Tyr1022/1023 phospho Antibody , phospho JAK1 Tyr1022/1023 Antibody , phospho JAK1 Antibody , Phospho JAK1 (Tyr1022/1023) Antibody , JAK1 (pY1022/1023) Antibody , Phospho JAK1 (pTyr1022/1023) Antibody
Cellular Localization: wholly intracellular, possibly membrane associated
CAS NO: 837422-57-8
Product: Aceglutamide
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic phospho peptide (Human). The sequence is conserved in mouse and pig.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.05% Sodium Azide; Constituents: 50% Glycerol, PBS, 1mg/ml BSA (IgG, protease free). pH 7.3
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18794348?dopt=Abstract
