Product Name: JAK1 antibody
Applications: ICC/IF, WB
Predicted Target Size: 133 kDa (note) (8)
Positive Controls: HepG2 , GL261 , C8D30 , NIH-3T3 , BCL-1 , Raw264.7
Form Supplied: Liquid
Concentration: 5.94 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity purified by Protein A.
Full Name: Janus kinase 1
Background: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq]
Synonyms: JAK1A antibody, JAK1B antibody, JTK3 antibody, JAK1 antibody, tyrosine-protein kinase JAK1 antibody, Janus kinase 1 antibody
Cellular Localization: Endomembrane system; Peripheral membrane protein
CAS NO: 194423-06-8
Product: Sulisobenzone
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human JAK1. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18927631?dopt=Abstract
