Product Name: JIP1 antibody
Applications: IHC-P, WB
Predicted Target Size: 78 kDa (note)
Positive Controls: HepG2
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: mitogen-activated protein kinase 8 interacting protein 1
Background: The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq]
Synonyms: IB1 antibody, JIP-1 antibody, JIP1 antibody, PRKM8IP antibody, MAPK8IP1 antibody, PRKM8 interacting protein antibody, JNK-interacting protein 1 antibody, IB-1 antibody, C-Jun-amino-terminal kinase-interacting protein 1 antibody, JNK MAP kinase scaffold protein 1 antibody, islet-brain 1 antibody, mitogen-activated protein kinase 8 interacting protein 1 antibody
Cellular Localization: Cytoplasm (By similarity) , Cytoplasm , perinuclear region (By similarity) , Nucleus (By similarity)
CAS NO: 945667-22-1
Product: Halothane
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human JIP1. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25966904?dopt=Abstract
