Product Name: JNK (phospho Tyr185)
Applications: IP, WB
Predicted Target Size: 46 (note)
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Tissue culture supernatant
Full Name:
Background: C-Jun N-terminal kinases (JNK) are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the AP-1 complex, and release and regulation of cytochome c . JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 . Unlike other JNK isoforms, JNK3 is only expressed in the heart and nervous system. JNK3 has been implicated in stress-induced neuronal apoptosis .
Synonyms: PRKM10, JNK3, FLJ33785, JNK3A, p54bSAPK, MAPK10, FLJ12099, MGC50974, p493F12, JNK1 (Phospho), Phospho JNK1
Cellular Localization:
CAS NO: 1047953-91-2
Product: Hexylresorcinol
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding tyrosine 223 of human JNK3 was used as immunogen.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Instruction: Store at -20 °C. Stable for 12 months from date of receipt.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,488.
Specificity: The antibody will detect JNK1 (pY185), JNK2(pY185) and JNK3 (pY223).
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24747641?dopt=Abstract
