Product Name: JNK2 antibody [N3C3]
Applications: ICC/IF, WB
Predicted Target Size: 48 kDa (note) (3)
Positive Controls: 293T , A431 , H1299 , HeLa , HepG2 , mouse brain
Form Supplied: Liquid
Concentration: 0.85 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: mitogen-activated protein kinase 9
Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this genes mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
Synonyms: JNK-55 antibody, JNK2 antibody, JNK2A antibody, JNK2ALPHA antibody, JNK2B antibody, JNK2BETA antibody, PRKM9 antibody, SAPK antibody, p54a antibody, p54aSAPK antibody, MAPK9 antibody, stress-activated protein kinase 1a antibody, MAP kinase 9 antibody, stress-activated protein kinase JNK2 antibody, Jun kinase antibody, MAPK 9 antibody, c-Jun N-terminal kinase 2 antibody, c-Jun kinase 2 antibody, mitogen-activated protein kinase 9 antibody
Cellular Localization:
CAS NO: 66611-26-5
Product: m-Tolyl acetate
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human JNK2. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23449393?dopt=Abstract
