Product Name: KA1 antibody
Applications: ELISA, ICC/IF, IHC-P, WB
Predicted Target Size:
Positive Controls: Blocking Peptide:Cat.No. GTX85044-PEP – Grik4 PeptideLysates:Cat. No. GTX27942 – Rat Brain Tissue Lysate
Form Supplied: Liquid
Concentration:
Purification: Affinity chromatography purified via peptide column
Full Name: glutamate receptor, ionotropic, kainate 4
Background: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.
Synonyms: Glutamate receptor KA1, Excitatory amino acid receptor1, Glutamate receptor ionotropic kainate4 precursor, EEA1, Glutamate receptor KA-1, Excitatory amino acid receptor 1, Grik4, Glutamate receptor ionotropic kainate 4 precursor, Glutamate receptor KA 1
Cellular Localization:
CAS NO: 840529-13-7
Product: Hexetidine
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen:
Antigen Species:
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Antibody is supplied in PBS containing 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for KA1.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22194611?dopt=Abstract
