Product Name: KDEL receptor antibody [KR-10]
Applications: ICC/IF, IP, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Unpurified
Full Name:
Background: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.
Synonyms: MGC139648
Cellular Localization: Integral membrane protein.
CAS NO: 122892-31-3
Product: Nalfurafine (hydrochloride)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Synthetic peptide conjugated to KLH, corresponding to amino acids 192-212 of Cow KDEL Receptor.
Antigen Species: Bovine
Species Reactivity: Human, Mouse, Dog, Monkey, Pig, Rat, Hamster, Rabbit, Xenopus laevis, Bovine
Conjugation: Unconjugated
Storage Buffer: Ascites
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18184809?dopt=Abstract
