Product Name: KDEL receptor antibody [N1C1]
Applications: WB
Predicted Target Size: 25 kDa (note)
Positive Controls: *Hamster BHK-21 cells
Form Supplied: Liquid
Concentration: 0.729 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
Background: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq]
Synonyms: ERD2 antibody, ERD2.1 antibody, HDEL antibody, PM23 antibody, KDELR1 antibody, ER lumen protein retaining receptor 1 antibody, KDEL endoplasmic reticulum protein retention receptor 1 antibody, putative MAPK-activating protein PM23 antibody, KDEL receptor 1 antibody, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 antibody
Cellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein
CAS NO: 54-71-7
Product: Nalfurafine
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human KDEL receptor. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Hamster
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17916803?dopt=Abstract