Product Name: KIR2DL3 antibody [GL183]
Applications: FACS, IP
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1.0 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified IgG
Full Name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several “framework” genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Synonyms: KIR-K7B Antibody , CD158B2 Antibody , NKAT2B Antibody , NKAT2A Antibody , KIRCL23 Antibody , KIR-023GB Antibody , KIR-K7C Antibody , CD158B Antibody , NKAT2 Antibody , NKAT Antibody , GL183 Antibody , P58 Antibody
Cellular Localization:
CAS NO: 1005491-05-3
Product: GSK503
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: NK cell clone E57 (Moretta et al. 1985).
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS, 0.09% Sodium Azide, 0.5% BSA
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. This product may contain precipitation. Recommend microcentrifugation before use.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody also recognises a 50kDa molecule in some NK clones, which is highly homologous to p58.2 in the extracellular domain, but has a shorter cytoplasmic tail (Moretta et al. 1985).
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21555366?dopt=Abstract
