Product Name: KIR2DL4 antibody, C-term
Applications: FACS, IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: Batch dependent mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A purified, followed by peptide affinity purification.
Full Name: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Synonyms: Killer cell immunoglobulinlike receptor2DL4, CD158 antigen-like family member D, CD_antigen=CD158d, CD158 antigenlike family member D, Killer cell inhibitory receptor 103AS, KIR103AS, G9P, Killer cell immunoglobulin-like receptor 2DL4, Flags: Precursor, KIR2DL4, Killer cell inhibitory recept, Killer cell inhibitory receptor103AS, KIR103AS, CDantigen=CD158d
Cellular Localization:
CAS NO: 54-96-6
Product: Naltrexone metabolite 6β-Naltrexol (hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: KLH conjugated synthetic peptide between 296-323 amino acids from the C-terminal region of human KIR2DL4.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS, 0.09% sodium azide.
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21170301?dopt=Abstract
