Product Name: KIR2DS4 antibody [N1C3-2]
Applications: IHC-P, WB
Predicted Target Size: 34 kDa (note)
Positive Controls: 293T , A431 , Jurkat , Raji
Form Supplied: Liquid
Concentration: 0.89 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several “framework” genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq]
Synonyms: CD158I antibody, KIR1D antibody, KIR412 antibody, KKA3 antibody, MGC120019 antibody, MGC125315 antibody, MGC125317 antibody, NKAT8 antibody, KIR2DS4 antibody, natural killer cell inhibitory receptor antibody, MHC class I NK cell receptor antibody, P58 natural killer cell receptor clones CL-39/CL-17 antibody, CD158 antigen-like family member I antibody, killer inhibitory receptor 4-1-2 antibody, p58 NK receptor CL-39/CL-17 antibody, natural killer-associated transcript 8 antibody, killer cell immunoglobulin-like receptor 2DS4 antibody, KIR antigen 2DS4 antibody, NKAT-8 antibody, “killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 antibody”
Cellular Localization: Cell membrane; Single-pass type I membrane protein
CAS NO: 98769-84-7
Product: Netupitant metabolite Netupitant N-oxide
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human KIR2DS4. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27226631?dopt=Abstract
