Product Name: KPNA6 antibody, Internal
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: karyopherin alpha 6 (importin alpha 7)
Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Synonyms: importin-alpha-S2, MGC17918, importin alpha 7 subunit, karyopherin alpha 6, KPNA7, KPNA6, IPOA7, karyopherin alpha 6 (importin alpha 7), importin alpha7 subunit, karyopherin alpha6 (importin alpha7), karyopherin alpha6, FLJ11249, importinalphaS2, importin alpha S2
Cellular Localization:
CAS NO: 101-31-5
Product: BMS-794833
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-STTGESVITREMVE
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for KPNA6.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18923081?dopt=Abstract
