Product Name: LAIR1 antibody, Internal
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: leukocyte-associated immunoglobulin-like receptor 1
Background: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Synonyms: CD305, LAIR-1, leukocyte-associated immunoglobulin-like receptor 1, LAIR1, leukocyteassociated immunoglobulinlike receptor 1, leukocyteassociated immunoglobulinlike receptor1, leukocyteassociated Iglike receptor1, leukocyte-associated Ig-like receptor 1, leukocyteassociated Iglike receptor 1, LAIR 1
Cellular Localization:
CAS NO: 83915-83-7
Product: Gamabufotalin
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-NDTEDVSQASPSE
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for LAIR1.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23748471?dopt=Abstract
