Product Name: Lamin A + C antibody [GT9712]
Applications: ICC/IF, IP, WB
Predicted Target Size: 65 KDa (note) (3)
Positive Controls: HeLa , HeLa nuclear
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity purified by Protein G.
Full Name: lamin A/C
Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq]
Synonyms: CDCD1 antibody , CDDC antibody , CMD1A antibody , CMT2B1 antibody , EMD2 antibody , FPL antibody, FPLD antibody, HGPS antibody, IDC antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, LMN1 antibody, LMNC antibody, LMNL1 antibody, PRO1 antibody, LMNA antibody, renal carcinoma antigen NY-REN-32 antibody, lamin A/C-like 1 antibody , prelamin-A/C antibody , 70 kDa lamin antibody , lamin A/C antibody
Cellular Localization: Nucleus
CAS NO: 1022150-12-4
Product: Mps1-IN-1
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b
Immunogen: Recombinant protein encompassing a sequence within the center region of human Lamin A/C. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23326564?dopt=Abstract
