Product Name: Lamin A + C antibody [mab636]
Applications: ICC/IF, IHC-Fr, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification:
Full Name: lamin A/C
Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Synonyms: HGPS Antibody , EMD2 Antibody , FPLD Antibody , lamin A/C Antibody , LDP1 Antibody , LMNA Antibody , LMNL1 Antibody , LMNC Antibody , FPL Antibody , LFP Antibody , CDCD1 Antibody , LGMD1B Antibody , IDC Antibody , CMT2B1 Antibody , PRO1 Antibody , FPLD2 A
Cellular Localization:
CAS NO: 761423-87-4
Product: Atractylenolide III
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b
Immunogen: Porcine lamin preparation.
Antigen Species: Human
Species Reactivity: Human, Mouse, Pig, Rat, Bovine
Conjugation: Unconjugated
Storage Buffer: tissue culture supernatant containing 0.05 % sodium azide
Storage Instruction: -20° C, Avoid Freeze/Thaw Cycles
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23471340?dopt=Abstract
