Product Name: Laminin antibody [LN82-13]
Applications: ELISA, IHC-Fr
Predicted Target Size:
Positive Controls:
Form Supplied:
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: IgG fraction
Full Name:
Background: Laminin, the most abundant structural and biologically active component in basement membranes, is a complex extracellular glycoprotein with an approximate molecular weight of 900 kD. It plays an important role in many aspects of the cell biology. Laminin is composed of one A chain (400 kD) one B1 chain (215 kD) and one B2 chain (205 kD) all held together by disulfide bonds. The molecule has a cross-like form with globular units near the ends of each chain, the sites where it is bound to Collagen IV, heparan sulfate, proteoglycan as well as to the surface of epithelial cells. Laminins from various species have common antigenic determinants. Laminin is only found in significant quantities in basement membranes, the thin extracellular matrices that surround epithelial tissue, nerve, fat cells and smooth, striated and cardiac muscle. It has been found to modulate cell differentiation, cell shaping and also cell movement because it appears to be an important cell substrate-adhesion protein. Variations in the expression of this protein have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. The greatest interest in laminin has been provoked by the discovery of its ability to promote neurite regeneration.
Synonyms:
Cellular Localization: Extracellular. Found in the basement membranes.
CAS NO: 85721-33-1
Product: β-Lapachone
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Full length protein (Human).
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.1% Sodium Azide; Constituents: 1% BSA, 10mM PBS. pH 7.4
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody specifically recognizes human laminin fragment gamma-1. This antibody does not inhibit cell adhesion.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21057503?dopt=Abstract
