Product Name: Langerin antibody [N2C3]
Applications: WB
Predicted Target Size: 37 kDa (note) (2)
Positive Controls: A549 , HeLa , HepG2 , C8D30 , NIH-3T3 , C2C12
Form Supplied: Liquid
Concentration: 0.94 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: CD207 molecule, langerin
Background: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. [provided by RefSeq]
Synonyms: CLEC4K antibody, CD207 antibody, Langerhans cell specific c-type lectin antibody, “C-type lectin domain family 4, member K antibody”, “CD207 antigen, langerin antibody”, C-type lectin domain family 4 member K antibody, “CD207 molecule, langerin antibody”
Cellular Localization: Membrane
CAS NO: 28860-95-9
Product: CTX-0294885
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human Langerin. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24427319?dopt=Abstract
