Product Name: LAP2 alpha antibody, C-term
Applications: ICC/IF, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Unpurified
Full Name: thymopoietin
Background: Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A- type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eu karyotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, and MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. While LAP 2 beta binds to B-type lamins at the nuclear periphery and was suggested to regulate nuclear lamina growth , LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent/salt-resistant nucleoskeletal structure.
Synonyms: Thymopoietin, TP, TMPO,
Cellular Localization: Expressed diffusely throughout the nucleus.
CAS NO: 72509-76-3
Product: LDC1267
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant LAP2α C terminus (amino acids 188-693)
Antigen Species:
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Antiserum containing PBS + 0.1% sodium azide
Storage Instruction: Store at 2-8°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Reacts with human, rat & mouse LAP2α
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24523901?dopt=Abstract
