Product Name: Lck (phospho Tyr393) antibody
Applications: ICC/IF, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: The antibody was purified by immunogen affinity chromatography.
Full Name: LCK proto-oncogene, Src family tyrosine kinase
Background: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]
Synonyms: IMD22 Antibody , LSK Antibody , LCK Antibody , pp58lck Antibody , p56lck Antibody , YT16 Antibody , LCK proto-oncogene, Src family tyrosine kinase Antibody
Cellular Localization:
CAS NO: 1572414-83-5
Product: Ro 48-8071
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LCK. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Storage Instruction: Shipped at 4 C. Upon delivery aliquot and store at -20 C for one year. Avoid freeze/thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Recognizes endogenous levels of LCK (pY393) protein.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20621658?dopt=Abstract
